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FGFR families: biological functions and therapeutic interventions in tumors

23 Sept 2023

Abstract excerpt

Abstract There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and autophosphorylates, thereby activating several key downstream pathways that play an important role in normal physiology, such as the Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase, phosphoinositide...

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PMID: 37750089
DOI: 10.1002/mco2.367

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