Novel potential oncogenic and druggable mutations of FGFRs recur in the kinase domain across cancer types.

Abstract excerpt

Fibroblast growth factor receptors (FGFRs) are recurrently altered by single nucleotide variants (SNVs) in many human cancers. The prevalence of SNVs in FGFRs depends on the cancer type. In some tumors, such as the urothelial carcinoma, mutations of FGFRs occur at very high frequency (up to 60%). Many characterized mutations occur in the extracellular or transmembrane domains, while fewer known mutations are...

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• Amino Acid Sequence
• Carcinogenesis
• Neoplasms
• Phosphorylation
• Protein Domains