Article
Role of fibroblast growth factor receptor 4 in cancer.
Cancer science - 1 Oct 2018
Tang Shuya, Hao Yilong, Yuan Yao, Liu Rui, Chen Qianming
Abstract excerpt
Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the...
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