Article

Prime editing outperforms homology-directed repair as a tool for CRISPR-mediated variant knock-in in zebrafish

2025-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Zebrafish serve as a valuable model organism for studying human genetic diseases. While generating knockout lines is relatively straightforward, introducing precise disease-specific genetic variants by knock-in (KI) remains challenging. KI lines, however, enable more accurate studies of molecular and physiological consequences of genetic diseases. Their generation is often hampered by low editin...

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Literature Corpus work: 7d2212b3-d017-541d-9836-fb63220d8c6e
DOI: 10.1101/2025.02.05.636566

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