Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish.

Nature communications - 4 Jul 2024

Qin Wei, Liang Fang, Lin Sheng-Jia, Petree Cassidy, Huang Kevin, Zhang Yu, Li Lin, Varshney Pratishtha, Mourrain Philippe, Liu Yanmei, Varshney Gaurav K

Abstract excerpt

Advancements in CRISPR technology, particularly the development of base editors, revolutionize genetic variant research. When combined with model organisms like zebrafish, base editors significantly accelerate and refine in vivo analysis of genetic variations. However, base editors are restricted by protospacer adjacent motif (PAM) sequences and specific editing windows, hindering their applicability to a broad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Genetically Modified

Share to CRISPR-Cas Systems

Share to Gene Editing

Share to INDEL Mutation

Share to RNA, Guide, CRISPR-Cas Systems

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 38965236
DOI: 10.1038/s41467-024-49943-1
PMCID: PMC11224239

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish.PMID 38965236Read ↗

TadA-Derived Cytosine Base Editor for Precise Genome Editing in ZebrafishSemantic proximity Read ↗

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction.Semantic proximity Read ↗

Sequence Context‐Agnostic TadA‐Derived Cytosine Base Editors for Genome‐Wide Editing in ZebrafishSemantic proximity Read ↗

Precise <i>in vivo</i> functional analysis of DNA variants with base editing using ACEofBASEs target predictionSemantic proximity Read ↗

SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafishSemantic proximity Read ↗

Engineering a precise adenine base editor with minimal bystander editing.Semantic proximity Read ↗

Precision genome editing using cytosine and adenine base editors in mammalian cells.Semantic proximity Read ↗

Precise generation of bystander-free mouse models with ABE9-SpRYSemantic proximity Read ↗

CRISPR-Cas9 DNA Base-Editing and Prime-Editing.Semantic proximity Read ↗

Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editingSemantic proximity Read ↗

Base Editing and Prime Editing: Potential Therapeutic Options for Rare and Common Diseases.Semantic proximity Read ↗

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.