Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes.

Journal of neuroinflammation - 10 Sept 2018

Du Ren-Hong, Zhou Yan, Xia Mei-Ling, Lu Ming, Ding Jian-Hua, Hu Gang

Abstract excerpt

BACKGROUND: α-Synuclein (α-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Dopamine D2 receptor (Drd2) has been regarded as a potential anti-inflammatory target in the therapy of neurodegenerative diseases. However, the effect of astrocytic Drd2 in α-Syn-induced neuroinflammation remains unclear. METHODS: The effect of Drd2 on neuroinflammation was examined in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Animals, Newborn

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Astrocytes

Share to beta-Arrestin 2

Share to Dopamine Agonists

Share to Embryo, Mammalian

Share to Receptors, Dopamine D2

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 30200997
DOI: 10.1186/s12974-018-1302-6
PMCID: PMC6131810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes.PMID 30200997Read ↗

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson’s DiseaseSemantic proximity Read ↗

Microglia Depletion Reduces Neurodegeneration and Remodels Extracellular Matrix in a Mouse Parkinson’s Disease Model Triggered by α-Synuclein OverexpressionSemantic proximity Read ↗

The interplay between CB <sub>2</sub> and NMDA receptors in Parkinson’s diseaseSemantic proximity Read ↗

Astrocytic expression of Parkinson's disease-related A53T alpha-synuclein causes neurodegeneration in mice.Semantic proximity Read ↗

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells-Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage.Semantic proximity Read ↗

Rapamycin protects dopaminergic neurons by suppressing TLR2 mediated neuroinflammation and enhancing autophagy in rotenone-induced PD miceSemantic proximity Read ↗

α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcriptionSemantic proximity Read ↗

Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.Semantic proximity Read ↗

Targeting NMDAR2A: Esketamine's Impact on BV2 Microglial Pro-inflammatory PolarizationSemantic proximity Read ↗

Expression of ??-synuclein in a human glioma cell line and its up-regulation by interleukin-1??Semantic proximity Read ↗

GPCR-mediated regulation of glial TNF productionSemantic proximity Read ↗

Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.