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Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2006

Klegeris Andis, Giasson Benoit I, Zhang Hong, Maguire John, Pelech Steven, McGeer Patrick L

Abstract excerpt

Autosomal dominant Parkinson disease (PD) is caused by duplication or triplication of the alpha-synuclein gene as well as by the A30P, E46K, and A53T mutations. The mechanisms are unknown. Reactive astrocytes in the substantia nigra of PD and MPTP-treated monkeys display high levels of the inflam...

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PMID: 17012252
DOI: 10.1096/fj.06-6183com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17012252-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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