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α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription

26 Oct 2024

Abstract excerpt

BACKGROUND: Autophagy dysfunction in glial cells is implicated in the pathogenesis of Parkinson's disease (PD). The previous study reported that α-synuclein (α-Syn) disrupted autophagy in cultured microglia. However, the mechanism of microglial autophagy dysregulation is poorly understood. METHODS: Two α-Syn-based PD models were generated via AAV-mediated α-Syn delivery into the mouse substantia nigra and...

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PMID: 39462396
DOI: 10.1186/s12974-024-03268-4

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