Article

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson’s Disease

2024-02-25

Abstract excerpt

<h4>Summary</h4> Pathological aggregation of α-Synuclein (α-Syn) and neuroinflammation are closely linked to Parkinson’s disease (PD). However, the specific regulators of the neuroinflammation caused by pathological α-syn remain obscure. In this study, we show that NOD2/RIPK2 signaling is a crucial regulator of neuroinflammation in PD. Pathological α-syn binds to NOD2, causing self-oligomerization and complex for...

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Literature Corpus work: c8082abb-6169-5c54-9159-39dbed09623d
DOI: 10.1101/2024.02.19.580982

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