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Article

Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells.

Journal of neuroinflammation - 26 Oct 2015

Yshii Lidia M, Denadai-Souza Alexandre, Vasconcelos Andrea R, Avellar Maria Christina W, Scavone Cristoforo

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease with characteristics and symptoms that are well defined. Nevertheless, its aetiology remains unknown. PD is characterized by the presence of Lewy bodies inside neurons. α-Synuclein (α-syn) is a soluble protein present in the pre-synaptic terminal of neurons. Evidence suggests that α-syn has a fundamental role in PD pathogenesis, given that it is...

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Identifiers

PMID: 26502720
DOI: 10.1186/s12974-015-0412-7
PMCID: PMC4623263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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