Article

Rapamycin protects dopaminergic neurons by suppressing TLR2 mediated neuroinflammation and enhancing autophagy in rotenone-induced PD mice

2023-05-11

Abstract excerpt

Microglia inflammation and autophagy play important roles in the initiation and progression of Parkinson’s disease (PD). Toll-like receptor 2 (TLR2) activation is closely related to microglial activation and enhances the cell-to-cell propagation of a-synuclein pathology. Clinical and preclinical samples also observed the impaired autophagy-lysosomal systems. As such, therapeutic strategies that inhibit TLR2 and/or...

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Literature Corpus work: c5f1348e-3642-5638-8884-1becef719661
DOI: 10.21203/rs.3.rs-2906856/v1

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