Article

GPCR-mediated regulation of glial TNF production

2026-06-16

Abstract excerpt

Neuromodulators generally act through G-protein-coupled receptors, but their effects on glia are not well defined. Here we examine the impact of various G-protein-coupled signaling pathways on glia, using the production of the pro-inflammatory cytokine tumor necrosis factor alpha (TNF) as a measure of activation. TNF is a major component of the innate immune response but is also an important regulator of synaptic...

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Literature Corpus work: 24f0c729-8cb8-5a30-8df6-e97d80ef591b
DOI: 10.64898/2026.06.12.731854

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