Article
Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease.
Nutrients - 6 Sept 2018
Milanovic Desanka, Petrovic Snjezana, Brkic Marjana, Avramovic Vladimir, Perovic Milka, Ivkovic Sanja, Glibetic Marija, Kanazir Selma
Abstract excerpt
Long-term fish oil (FO) supplementation is able to improve Alzheimer's disease (AD) pathology. We aimed to determine the impact of short-term fish oil (FO) intake on phospholipids composition and plaque pathology in 5xFAD mice, a widely used animal model of AD. A 3-week-long FO supplementation administered at 3 months of age decreased the number of dense core plaques in the 5xFAD cortex and changed phospholipids...
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