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Article

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.

Neurobiology of aging - 1 Sept 2013

Lim Wei Ling Florence, Lam Sin Man, Shui Guanghou, Mondal Alinda, Ong Daniel, Duan Xinrui, Creegan Rhona, Martins Ian J, Sharman Matthew J, Taddei Kevin, Verdile Giuseppe, Wenk Markus R, Martins Ralph Nigel

Abstract excerpt

Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer's disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE ε3 and ε4 knock-in mice...

Topics

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Apolipoprotein E3
Apolipoprotein E4
Cholesterol, Dietary
Cholesterol Esters
Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Knock-In Techniques

Lipid Metabolism

Mass Spectrometry

Source

Identifiers

PMID: 23601809
DOI: 10.1016/j.neurobiolaging.2013.03.012

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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