Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes.

The Journal of nutritional biochemistry - 1 Sept 2026

Andriambelo Bijou, Vachon Annick, Dansereau Marc-André, Dumais Élizabeth, Flamand Nicolas, Laurent Benoit, Plourde Mélanie

Abstract excerpt

In a previous study, we showed that oral supplementation with lysophosphatidylcholine (LPC)-bound omega-3 fatty acids (n-3) increases cortical eicosapentaenoic acid (EPA, C20:5n-3) but not docosahexaenoic acid (DHA, C22:6n-3) in an apolipoprotein E (APOE)- and duration-dependent manner. This may reflect DHA retention in blood-brain interfaces, such as microvessels (MV) and choroid plexus (ChP). The objective of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dietary Supplements

Share to Docosahexaenoic Acids

Share to Eicosapentaenoic Acid

Share to Fatty Acids, Omega-3

Share to Microvessels

Source

Identifiers

PMID: 41962782
DOI: 10.1016/j.jnutbio.2026.110376

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes.PMID 41962782Read ↗

Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele.Semantic proximity Read ↗

Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele.Semantic proximity Read ↗

The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice.Semantic proximity Read ↗

Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice.Semantic proximity Read ↗

Association of oily fish intake, sex, age, BMI and APOE genotype with plasma long-chain n-3 fatty acid composition.Semantic proximity Read ↗

Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline.Semantic proximity Read ↗

Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.Semantic proximity Read ↗

Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids.Semantic proximity Read ↗

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.Semantic proximity Read ↗

Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprintSemantic proximity Read ↗

Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.