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Article

Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.

International journal of molecular sciences - 29 May 2020

Park Yong Ho, Shin Soo Jung, Kim Hyeon Soo, Hong Sang Bum, Kim Sujin, Nam Yunkwon, Kim Jwa-Jin, Lim Kyu, Kim Jong-Seok, Kim Jin-Il, Jeon Seong Gak, Moon Minho

Abstract excerpt

It has been reported that damage to the mitochondria affects the progression of Alzheimer's disease (AD), and that mitochondrial dysfunction is improved by omega-3. However, no animal or cell model studies have confirmed whether omega-3 inhibits AD pathology related to mitochondria deficits. In this study, we aimed to (1) identify mitigating effects of endogenous omega-3 on mitochondrial deficits and AD pathology...

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Identifiers

PMID: 32486013
DOI: 10.3390/ijms21113879
PMCID: PMC7312360

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