Article
Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Apr 2025
Andriambelo Bijou, Vachon Annick, Dansereau Marc-André, Laurent Benoit, Plourde Mélanie
Abstract excerpt
BACKGROUND: Several mechanisms have been proposed for the brain uptake of omega-3 fatty acids (n-3), including passive diffusion of the unesterified form and the use of Mfsd2a transporter for the lysophosphatidylcholine (LPC) form. We hypothesize that the accumulation of LPC n-3 in the brain is lower in mice carrying the apolipoprotein E ε4 allele (APOE4), a major genetic risk factor for developing sporadic...
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