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Article

Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele.

The Journal of nutritional biochemistry - 1 Jan 2023

Husain Mohammed Amir, Vachon Annick, Chouinard-Watkins Raphael, Vandal Milène, Calon Frédéric, Plourde Mélanie

Abstract excerpt

The metabolism of docosahexaenoic acid (DHA), an omega-3 fatty acid, is different in carriers of APOE4, the main genetic risk factor for late-onset Alzheimer's disease. The brain relies on the plasma DHA pool for its need, but the plasma-liver-brain axis in relation to cognition remains obscure. We hypothesized that this relationship is compromised in APOE4 mice considering the differences in fatty acid...

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PMID: 36220526
DOI: 10.1016/j.jnutbio.2022.109181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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