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Article

HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

Nature genetics - 1 Dec 2009

Thomas Rasmi, Apps Richard, Qi Ying, Gao Xiaojiang, Male Victoria, O'hUigin Colm, O'Connor Geraldine, Ge Dongliang, Fellay Jacques, Martin Jeffrey N, Margolick Joseph, Goedert James J, Buchbinder Susan, Kirk Gregory D, Martin Maureen P, Telenti Amalio, Deeks Steven G, Walker Bruce D, Goldstein David, McVicar Daniel W, Moffett Ashley, Carrington Mary

Abstract excerpt

A variant 35 kb upstream of the HLA-C gene (-35C/T) was previously shown to associate with HLA-C mRNA expression level and steady-state plasma HIV RNA levels. We genotyped this variant in 1,698 patients of European ancestry with HIV. Individuals with known seroconversion dates were used for disea...

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Identifiers

PMID: 19935663
DOI: 10.1038/ng.486
PMCID: PMC2887091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19935663-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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