Influence of HLA-C expression level on HIV control.

doi:10.1126/science.1232685

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Article

Influence of HLA-C expression level on HIV control.

Science (New York, N.Y.) - 5 Apr 2013

Apps Richard, Qi Ying, Carlson Jonathan M, Chen Haoyan, Gao Xiaojiang, Thomas Rasmi, Yuki Yuko, Del Prete Greg Q, Goulder Philip, Brumme Zabrina L, Brumme Chanson J, John Mina, Mallal Simon, Nelson George, Bosch Ronald, Heckerman David, Stein Judy L, Soderberg Kelly A, Moody M Anthony, Denny Thomas N, Zeng Xue, Fang Jingyuan, Moffett Ashley, Lifson Jeffrey D, Goedert James J, Buchbinder Susan, Kirk Gregory D, Fellay Jacques, McLaren Paul, Deeks Steven G, Pereyra Florencia, Walker Bruce, Michael Nelson L, Weintrob Amy, Wolinsky Steven, Liao Wilson, Carrington Mary

Abstract excerpt

A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C...

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PMID: 23559252
DOI: 10.1126/science.1232685
PMCID: PMC3784322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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