Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure.

Environment international - 1 Dec 2018

Huen Karen, Solomon Olivia, Kogut Katherine, Eskenazi Brenda, Holland Nina

Abstract excerpt

PON1 is a multifunctional enzyme involved in oxidative stress and detoxification of some organophosphate (OP) pesticides. It has been associated with nervous system diseases like Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and autism. We previously found that PON1 susceptible genotypes were associated with lower IQ scores in children. Epigenetic marks, such as DNA methylation, can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryldialkylphosphatase
Share to Cognition
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maternal-Fetal Exchange

Share to Memory, Short-Term

Share to Mexican Americans

Share to Organophosphates

Share to Pesticides

Source

Open in PubMed Open full text

Identifiers

PMID: 30172926
DOI: 10.1016/j.envint.2018.08.044
PMCID: PMC6242297

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure.PMID 30172926Read ↗

Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhoodSemantic proximity Read ↗

Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood.Semantic proximity Read ↗

Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review.Semantic proximity Read ↗

Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk-an exploratory study.Semantic proximity Read ↗

Association Studies of Environmental Exposures, DNA Methylation and Children’s Cognitive, Behavioral, and Mental Health ProblemsSemantic proximity Read ↗

Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms.Semantic proximity Read ↗

PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genesSemantic proximity Read ↗

Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes.Semantic proximity Read ↗

Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.Semantic proximity Read ↗

Genetic Susceptibility to Neurotoxicity Related to Prenatal Inorganic Arsenic Exposure in Young Spanish Children.Semantic proximity Read ↗

Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.Semantic proximity Read ↗

Increased influence of genetic variation on PON1 activity in neonates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.