Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms.

Environmental health perspectives - 1 Oct 2009

Huen Karen, Harley Kim, Brooks Jordan, Hubbard Alan, Bradman Asa, Eskenazi Brenda, Holland Nina

Abstract excerpt

BACKGROUND: Paraoxonase 1 (PON1) is an enzyme that detoxifies activated organophosphorus pesticides (OPs) and is also involved in oxidative stress pathways. OBJECTIVES: PON1 activity in newborns is lower than in adults, but the ontogeny of PON1 activity is poorly characterized in young children. We examined the effects of age and PON1 genotype on enzyme activity in a birth cohort of Mexican-American children....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Gene Expression Regulation, Developmental

Share to Genotype

Share to Infant

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20019917
DOI: 10.1289/ehp.0900870
PMCID: PMC2790521

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms.PMID 20019917Read ↗

Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes.Semantic proximity Read ↗

Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.Semantic proximity Read ↗

Increased influence of genetic variation on PON1 activity in neonates.Semantic proximity Read ↗

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review.Semantic proximity Read ↗

Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.Semantic proximity Read ↗

Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women.Semantic proximity Read ↗

Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns.Semantic proximity Read ↗

Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects.Semantic proximity Read ↗

Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood.Semantic proximity Read ↗

RETRACTED: Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico.Semantic proximity Read ↗

Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.