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Article

Increased influence of genetic variation on PON1 activity in neonates.

Environmental health perspectives - 1 Aug 2003

Chen Jia, Kumar Madhu, Chan Wendy, Berkowitz Gertrud, Wetmur James G

Abstract excerpt

PON1 (paraoxonase-1) detoxifies organophosphates by cleavage of active oxons before they have a chance to inhibit cholinesterases. The corresponding gene PON1 has common polymorphisms in both the promoter (-909, -162, -108) and the coding region (L55M, Q192R). The five PON1 genotypes were determi...

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Source

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Identifiers

PMID: 12928148
DOI: 10.1289/ehp.6105
PMCID: PMC1241633

Genes

PON1
PON2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12928148-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Increased influence of genetic variation on PON1 activity in neonates.PMID 12928148Read ↗

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