Article
Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk-an exploratory study.
Clinical epigenetics - 1 Jan 2017
Declerck Ken, Remy Sylvie, Wohlfahrt-Veje Christine, Main Katharina M, Van Camp Guy, Schoeters Greet, Vanden Berghe Wim, Andersen Helle R
Abstract excerpt
BACKGROUND: Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. However, the molecular mechanisms involved have not yet been resolved. It was hypothesized that epigenetics might be involved. The...
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