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Article

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts.

Journal of neuroinflammation - 28 Aug 2018

Weishaupt Nina, Liu Qingfan, Shin Sheojung, Singh Ramandeep, Agca Yuksel, Agca Cansu, Hachinski Vladimir, Whitehead Shawn Narain

Abstract excerpt

BACKGROUND: Most of the animal models commonly used for preclinical research into Alzheimer's disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that does not develop AD-like pathology spontaneously with age, but does develop pathology following vascular stress. To further...

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Identifiers

PMID: 30153843
DOI: 10.1186/s12974-018-1273-7
PMCID: PMC6114740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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