Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.

Abstract excerpt

The etiology of the more common (sporadic) forms of Alzheimer's disease (AD) remains unknown, although age is the most important risk factor. Nevertheless, interactions between environmental risk factors and genetic background may also influence the onset and progression of sporadic AD. Chronic stress, associated with altered memory and other neurological processes, is thought to influence the pathogenesis of AD....

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