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Article

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Plucińska Kaja, Crouch Barry, Yeap Jie M, Stoppelkamp Sandra, Riedel Gernot, Platt Bettina

Abstract excerpt

Gene mutations within amyloid precursor protein (APP or AβPP) and/or presenilin 1 (PS1) genes are determinants of familial Alzheimer's disease (fAD) and remain fundamental for experimental models. Here, we generated a neuronal knock-in mouse (PLB2APP) with mutated human APPSwe/Lon and investigated histopathology and behavioral phenotypes. Additionally, PLB2APP mice were cross-bred with a presenilin (PS1A246E)...

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Source

Identifiers

PMID: 30040726
DOI: 10.3233/JAD-180336

Genes

APP
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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