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Article

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 2003

Richards J Grayson, Higgins Guy A, Ouagazzal Abdel-Mouttalib, Ozmen Laurence, Kew James N C, Bohrmann Bernd, Malherbe Pari, Brockhaus Manfred, Loetscher Hansruedi, Czech Christian, Huber Gerda, Bluethmann Horst, Jacobsen Helmut, Kemp John A

Abstract excerpt

Transgenic mice, expressing mutant beta-amyloid precursor proteins (betaAPPs), have lead to a better understanding of the pathophysiological processes in Alzheimer's disease (AD). In many of these models, however, the temporal development of cognitive decline and the relationship to Abeta deposit...

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PMID: 14523101
PMCID: PMC6740398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14523101-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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