A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

doi:10.1016/j.nbd.2008.03.005

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Article

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.

Neurobiology of disease - 1 Jul 2008

Liu Li, Orozco Ian J, Planel Emmanuel, Wen Yi, Bretteville Alexis, Krishnamurthy Pavan, Wang Lili, Herman Mathieu, Figueroa Helen, Yu W Haung, Arancio Ottavio, Duff Karen

Abstract excerpt

In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the previously reported transgenic APP overexpressing rat models developed AD-like beta-amyloid (Abeta) deposits, or age-related learning and memory deficits. In the present study, we have characterized a transgenic rat model overexpressing...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Animals, Genetically Modified
Brain
Cognition Disorders
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Excitatory Postsynaptic Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoblotting

Immunohistochemistry

Male

Maze Learning

Mutation

Neuronal Plasticity

Organ Culture Techniques

Plaque, Amyloid

Presenilins

Source

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Identifiers

PMID: 18504134
DOI: 10.1016/j.nbd.2008.03.005
PMCID: PMC8995509

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