Article
Adipose Tissue Transferrin and Insulin Resistance.
The Journal of clinical endocrinology and metabolism - 1 Nov 2018
McClain Donald A, Sharma Neeraj K, Jain Shalini, Harrison Alexandria, Salaye Lipika N, Comeau Mary E, Langefeld Carl D, Lorenzo Felipe R, Das Swapan K
Abstract excerpt
Context: Excessive body iron stores are a risk factor for decreased insulin sensitivity (SI) and diabetes. We hypothesized that transcriptional dysregulation of genes involved in iron metabolism in adipocytes causes insulin resistance. Objective and Design: To define the genetic regulation of iron metabolism and its role in SI, we used gene expression, genotype, and SI data from an African American cohort (N =...
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