Article

A Mouse Model of Low Adipocyte Transferrin Recapitulates the Phenotype of a Human Genetic Polymorphism Associated with Insulin Sensitivity and Transferrin Expression

2023-08-31

Abstract excerpt

Transferrin (TF) is a key iron carrier protein. Studies in human cohorts and in cultured adipocytes suggested that decreased transferrin expression and intracellular iron in adipocytes leads to impaired insulin responsiveness and causes differential expression of genes involved in metabolism, insulin action, and obesity. While suggestive, these studies did not definitively prove in an intact organism that altering...

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Literature Corpus work: 9776d5ef-5b0d-5583-8e95-ac808c2a2c0b
DOI: 10.20944/preprints202308.2142.v1

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