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High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissue

29 Nov 2023

Abstract excerpt

White adipose tissue (WAT) is important for metabolic homeostasis. We established the differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and patients with type 2 diabetes (T2D) and the response to 8 weeks of high-intensity interval training (HIIT). Using a high-throughput and reproducible mass spectrometry-based proteomics pipeline, we identified 3773 proteins and found that...

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PMID: 38019916
DOI: 10.1126/sciadv.adi7548

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