Functional Iron-Transport Genes-TF and TMPRSS6-As Genetic Determinants of Transferrin and Fasting Glucose in a Kazakh Adult Cohort: A Whole-Exome Sequencing Pilot Study.

Abstract excerpt

Iron metabolism has long been linked to metabolic syndrome (MetS), but it is still unclear at which step-iron sensing, hepcidin regulation, export, transport, or storage-genetic variation matters the most. There are almost no studies on iron metabolism genes in Kazakhs in particular. Using whole-exome sequencing (WES) data from 96 Kazakh adults (52 with MetS), we examined 18 SNPs across six iron metabolism...

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