Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

doi:10.1093/hmg/ddq552

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Article

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

Human molecular genetics - 15 Mar 2011

Pichler Irene, Minelli Cosetta, Sanna Serena, Tanaka Toshiko, Schwienbacher Christine, Naitza Silvia, Porcu Eleonora, Pattaro Cristian, Busonero Fabio, Zanon Alessandra, Maschio Andrea, Melville Scott A, Grazia Piras Maria, Longo Dan L, Guralnik Jack, Hernandez Dena, Bandinelli Stefania, Aigner Elmar, Murphy Anthony T, Wroblewski Victor, Marroni Fabio, Theurl Igor, Gnewuch Carsten, Schadt Eric, Mitterer Manfred, Schlessinger David, Ferrucci Luigi, Witcher Derrick R, Hicks Andrew A, Weiss Günter, Uda Manuela, Pramstaller Peter P

Abstract excerpt

The genetic determinants of variation in iron status are actively sought, but remain incompletely understood. Meta-analysis of two genome-wide association (GWA) studies and replication in three independent cohorts was performed to identify genetic loci associated in the general population with serum levels of iron and markers of iron status, including transferrin, ferritin, soluble transferrin receptor (sTfR) and...

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Identifiers

PMID: 21208937
DOI: 10.1093/hmg/ddq552
PMCID: PMC3043660

Genes

TMPRSS6
HFE
TFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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