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Article

Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.

Prostaglandins & other lipid mediators - 1 Sept 2018

Oni-Orisan Akinyemi, Cresci Sharon, Jones Philip G, Theken Katherine N, Spertus John A, Lee Craig R

Abstract excerpt

Inhibition of soluble epoxide hydrolase (sEH, EPHX2) elicits potent cardiovascular protective effects in preclinical models of ischemic cardiovascular disease (CVD), and genetic polymorphisms in EPHX2 have been associated with developing ischemic CVD in humans. However, it remains unknown whether EPHX2 variants are associated with prognosis following an ischemic CVD event. We evaluated the association between...

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Identifiers

PMID: 30096423
DOI: 10.1016/j.prostaglandins.2018.07.005
PMCID: PMC6162147

Genes

EPHX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.PMID 30096423Read ↗

A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank.Semantic proximity Read ↗

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.Semantic proximity Read ↗

Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.Semantic proximity Read ↗

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Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.Semantic proximity Read ↗

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