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Article

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.

Human molecular genetics - 15 May 2006

Lee Craig R, North Kari E, Bray Molly S, Fornage Myriam, Seubert John M, Newman John W, Hammock Bruce D, Couper David J, Heiss Gerardo, Zeldin Darryl C

Abstract excerpt

Endothelial dysfunction contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes epoxyeicosatrienoic acids in the vasculature and regulates endothelial function. We sought to determine whether genetic variation in soluble epoxide hydrolase (EPHX2) was associated with the risk of CHD. We genotyped 2,065 Atherosclerosis Risk in Communities study participants (1,085...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16595607
DOI: 10.1093/hmg/ddl085
PMCID: PMC2040335

Genes

EPHX2

Provenance

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Related research

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Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.PMID 16595607Read ↗

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The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.Semantic proximity Read ↗

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Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.Semantic proximity Read ↗

Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.Semantic proximity Read ↗

Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

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