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Article

Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans.

Hypertension (Dallas, Tex. : 1979) - 1 Jan 2011

Lee Craig R, Pretorius Mias, Schuck Robert N, Burch Lauranell H, Bartlett Jackie, Williams Scott M, Zeldin Darryl C, Brown Nancy J

Abstract excerpt

Cytochrome P450-derived epoxyeicosatrienoic acids are potent vasodilators in preclinical models and are hydrolyzed by soluble epoxide hydrolase (EPHX2). Associations between the EPHX2 Lys55Arg and Arg287Gln polymorphisms and cardiovascular disease risk have been reported; however, their impact on vascular function in humans has not been investigated. In 265 volunteers (198 white, 67 black American), forearm blood...

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Source

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Identifiers

PMID: 21098312
DOI: 10.1161/HYPERTENSIONAHA.110.161695
PMCID: PMC3020911

Genes

EPHX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans.PMID 21098312Read ↗

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Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease.Semantic proximity Read ↗

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