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Article

Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 2008

Corenblum Mandi J, Wise Vance E, Georgi Katrin, Hammock Bruce D, Doris Peter A, Fornage Myriam

Abstract excerpt

Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids and represents a novel therapeutic target in cardiovascular disease treatment. We investigated the relationship among sequence variation in the sEH gene (Ephx2), sEH function, and risk of end-organ injury in strains of spontaneously hypertensive rat (SHRs) differing in their susceptibility to develop brain vascular disease. Brain Ephx2...

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Source

Identifiers

PMID: 18086949
DOI: 10.1161/HYPERTENSIONAHA.107.102160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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