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Article

Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking.

Atherosclerosis - 1 Jan 2007

Wei Qi, Doris Peter A, Pollizotto Martin V, Boerwinkle Eric, Jacobs David R, Siscovick David S, Fornage Myriam

Abstract excerpt

Soluble epoxide hydrolase (EPHX2) catalyses the degradation of the vasoactive and anti-inflammatory epoxyeicosatrienoic acids and may play a role in the pathophysiology of atherosclerosis. 1337 African-Americans and 1645 Whites from the CARDIA study were genotyped for 22 and 15 EPHX2 single nucle...

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Source

Identifiers

PMID: 16545818
DOI: 10.1016/j.atherosclerosis.2006.02.021

Genes

EPHX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16545818-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking.PMID 16545818Read ↗

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.Semantic proximity Read ↗

Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study.Semantic proximity Read ↗

The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.Semantic proximity Read ↗

A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank.Semantic proximity Read ↗

Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.Semantic proximity Read ↗

Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.Semantic proximity Read ↗

Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease.Semantic proximity Read ↗

Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.Semantic proximity Read ↗

Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.Semantic proximity Read ↗

Polymorphisms in human soluble epoxide hydrolase.Semantic proximity Read ↗

Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease.Semantic proximity Read ↗

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