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Article

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study.

Diabetes & vascular disease research - 1 Jun 2008

Burdon Kathryn P, Lehtinen Allison B, Langefeld Carl D, Carr J Jeffrey, Rich Stephen S, Freedman Barry I, Herrington David, Bowden Donald W

Abstract excerpt

Epoxide hydrolase is involved in metabolism of vasoactive and anti-inflammatory epoxyeicosatrienoic acids to their corresponding diols. Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene. We investigated EPHX2 for association with subclinical CVD in European American (EA) and African American (AA) families from the Diabetes Heart Study. The R287Q polymorphism was associated...

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Identifiers

PMID: 18537101
DOI: 10.3132/dvdr.2008.021
PMCID: PMC4882928

Genes

EPHX2

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Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study.PMID 18537101Read ↗

A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank.Semantic proximity Read ↗

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No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients.Semantic proximity Read ↗

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.Semantic proximity Read ↗

Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans.Semantic proximity Read ↗

<i>EPHX1</i> mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescenceSemantic proximity Read ↗

In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy.Semantic proximity Read ↗

Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease.Semantic proximity Read ↗

Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.Semantic proximity Read ↗

Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.Semantic proximity Read ↗

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