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Article

Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.

Pharmacogenetics and genomics - 1 Feb 2010

Fava Cristiano, Montagnana Martina, Danese Elisa, Almgren Peter, Hedblad Bo, Engström Gunnar, Berglund Göran, Minuz Pietro, Melander Olle

Abstract excerpt

OBJECTIVES: The soluble epoxide hydrolase (gene name EPHX2) is responsible for metabolism of 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in previous studies....

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Source

Identifiers

PMID: 20065888
DOI: 10.1097/FPC.0b013e3283349ec9

Genes

EPHX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes.PMID 20065888Read ↗

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