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Article

Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2010

Merkel Matthias J, Liu Lijuan, Cao Zhiping, Packwood William, Young Jennifer, Alkayed Nabil J, Van Winkle Donna M

Abstract excerpt

Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET. EETs are derived from arachidonic acid via P-450 epoxygenases and are cardioprotective. We tested the hypothesis that sEH deficiency and pharmacological inhibition elicit tolerance to ischemia via EET-mediated STAT3 signaling in vitro and in vivo. In addition, the relevance of single nucleotide polymorphisms (SNPs)...

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Share to Cell Survival
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 20008276
DOI: 10.1152/ajpheart.00533.2009
PMCID: PMC2822583

Genes

STAT3
EPHX2
RGR
JAK2
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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