Article
Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery.
PloS one - 1 Jan 2017
Shuey Megan M, Billings Frederic T, Wei Shouzou, Milne Ginger L, Nian Hui, Yu Chang, Brown Nancy J
Abstract excerpt
Twenty to thirty percent of patients undergoing cardiac surgery develop acute kidney injury (AKI). In mice, inhibition of soluble epoxide hydrolase (sEH) attenuates renal injury following ischemia-reperfusion. We tested the hypothesis that functional variants of EPHX2, encoding sEH, are associated with AKI after cardiac surgery. We genotyped patients in two independent cardiac surgery cohorts for functional EPHX2...
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