Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study.

doi:10.1001/jamacardio.2018.2287

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Article

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study.

JAMA cardiology - 1 Sept 2018

Cai Tianxi, Zhang Yichi, Ho Yuk-Lam, Link Nicholas, Sun Jiehuan, Huang Jie, Cai Tianrun A, Damrauer Scott, Ahuja Yuri, Honerlaw Jacqueline, Huang Jie, Costa Lauren, Schubert Petra, Hong Chuan, Gagnon David, Sun Yan V, Gaziano J Michael, Wilson Peter, Cho Kelly, Tsao Philip, O'Donnell Christopher J, Liao Katherine P

Abstract excerpt

Importance: Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SNPs) who are not receiving IL6R blocking therapy have biomarker profiles similar to those treated with IL6R blockers. This gene-drug pair provides an example to test...

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PMID: 30090940
DOI: 10.1001/jamacardio.2018.2287
PMCID: PMC6233652

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