Human Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.

doi:10.1161/ATVBAHA.124.321988

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Article

Human Genetic Evidence to Inform Clinical Development of IL-6 Signaling Inhibition for Abdominal Aortic Aneurysm.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2025

Burgess Stephen, Cronjé Héléne T, deGoma Emil, Chyung Yung, Gill Dipender

Abstract excerpt

BACKGROUND: Abdominal aortic aneurysm (AAA) represents a significant cause of mortality, yet no medical therapies have proven efficacious. The aim of the current study was to leverage human genetic evidence to inform clinical development of IL-6 (interleukin-6) signaling inhibition for the treatment of AAA. METHODS: Associations of rs2228145, a missense variant in the IL6R gene region, are expressed per...

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PMID: 39633572
DOI: 10.1161/ATVBAHA.124.321988
PMCID: PMC7617413

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IL6R

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