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Article

IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk

26 Aug 2025

Abstract excerpt

Human genetics supports a causal involvement of IL-6 signaling in atherosclerotic cardiovascular disease, prompting the clinical development of anti-IL-6 therapies. Genetic evidence has historically focused on IL6R missense variants, but emerging cardiovascular treatments target IL-6, not its receptor, questioning the translatability of genetic findings. Here we develop a genetic instrument for IL-6 signaling...

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PMID: 40858837
DOI: 10.1038/s44161-025-00700-7

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