Article

Differential Associations of Interleukin 6 Receptor Variant Across Genetic Ancestries and Implications for Targeted Therapies

2022-09-25

Abstract excerpt

Genomic data are increasingly incorporated into high-throughput approaches such as the Phenome-Wide Association Study (PheWAS) to query potential effects of targeted therapies. Genetic variants, such as the interleukin-6 receptor ( IL6R ) genetic variant rs2228145 (Asp358Ala), have been identified with a downstream effect similar to the drug, e.g., tocilizumab which targets IL6R, and can be used to screen for pote...

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Literature Corpus work: 3cb2ec6f-8e1c-5dea-a0f6-1b584483547e
DOI: 10.1101/2022.09.24.22280325

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