Article

Human genetic evidence to inform clinical development of interleukin-6 signaling inhibition for abdominal aortic aneurysm

2024-09-15

Abstract excerpt

<h4>Background</h4> Abdominal aortic aneurysm (AAA) represents a significant cause of mortality, yet no medical therapies have proven efficacious. The aim of the current study was to leverage human genetic evidence to inform clinical development of interleukin-6 (IL6) signaling inhibition for treatment of AAA. <h4>Methods</h4> We focused on rs2228145, a missense variant in the IL6R gene region whose associations a...

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Literature Corpus work: acbc5d30-da95-59a2-8887-3b0888a8f82a
DOI: 10.1101/2024.09.14.24313670

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