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Article

Interleukin-6 receptor pathways in abdominal aortic aneurysm

30 Oct 2012

Abstract excerpt

METHODS: We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6)...

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PMID: 23111417
DOI: 10.1093/eurheartj/ehs354

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