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Article

Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy.

Scientific reports - 5 Apr 2024

Wang Xuan, Liu Molei, Nogues Isabelle-Emmanuella, Chen Tony, Xiong Xin, Bonzel Clara-Lea, Zhang Harrison, Hong Chuan, Xia Yin, Dahal Kumar, Costa Lauren, Cui Jing, Gaziano J Michael, Kim Seoyoung C, Ho Yuk-Lam, Cho Kelly, Cai Tianxi, Liao Katherine P

Abstract excerpt

The Phenome-Wide Association Study (PheWAS) is increasingly used to broadly screen for potential treatment effects, e.g., IL6R variant as a proxy for IL6R antagonists. This approach offers an opportunity to address the limited power in clinical trials to study differential treatment effects across patient subgroups. However, limited methods exist to efficiently test for differences across subgroups in the...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin-6

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Identifiers

PMID: 38580710
DOI: 10.1038/s41598-024-54063-3
PMCID: PMC10997791

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